Autoclave was a short-lived indie rock band based in Washington D.C., USA. Formed in the summer of 1990, the group consisted of Christina Billotte (vocals and electric bass guitar), Mary Timony (electric guitar and vocals), Nikki Chapman (electric guitar and vocals), and Melissa Berkoff (drum set).

The group became known for their intelligent, slightly off-kilter brand of rock, which featured the use of compound and changing meters, thus affiliating them with the "math rock" movement.

The group broke up in May 1991, with Timony joining Helium and Billotte forming Slant 6.
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